AMINOGLYCOSIDE ACETYLTRANSFERASE-3-IV (AACC4) AND HYGROMYCIN-B 4-I PHOSPHOTRANSFERASE (HPHB) IN BACTERIA ISOLATED FROM HUMAN AND ANIMAL SOURCES

被引：28

作者：

SALAUZE, D ^{[1
]}

OTAL, I ^{[1
]}

GOMEZLUS, R ^{[1
]}

DAVIES, J ^{[1
]}

机构：

[1] UNIV ZARAGOZA, FAC MED, DEPT BIOMED & SALUD PUBL, E-50009 ZARAGOZA, SPAIN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 10期

关键词：

D O I：

10.1128/AAC.34.10.1915

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Members of the family Enterobacteriaceae harboring an enzyme of the aminoglycoside acetyltransferase 3 class (AAC-3-IV) (apramycin and gentamicin resistance) and hygromycin B phosphotransferase 4 (HPH-4-I) (hygromycin B resistance) have been isolated from human clinical sources in Europe. A cluster of genes containing IS140, aacC4, and hphB was found in these strains. We demonstrate by Southern hybridization that this cluster is identical to the operon found in animals that also insertion sequences belonging to the IS6 family. This provides another example of presumptive transfer of antibiotic resistance genes between bacteria of animal and human origin.

引用

页码：1915 / 1920

页数：6