IMMUNOGENICITY STUDIES ON DIPHTHERIA TOXOID LOADED BIODEGRADABLE MICROSPHERES

被引：29
|
作者：
SINGH, M [1 ]
SINGH, O [1 ]
SINGH, A [1 ]
TALWAR, GP [1 ]
机构：
[1] PHARMAX CORP LTD,NEW DELHI 110020,INDIA
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 85卷 / 1-3期
关键词：
VACCINE DELIVERY; IMMUNE RESPONSE; ANTIBODY TITER; POLYMER EROSION; ELISA;
D O I：
10.1016/0378-5173(92)90157-W
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Diphtheria toxoid loaded polylactide microspheres were prepared using the solvent evaporation method. The vaccine loaded microspheres were subjected to in vitro antigen release studies and in vivo immune response tests. The immunogenicity of the vaccine after microencapsulation was compared to that against diphtheria toxoid given in the conventional three injection schedule on alum as an adjuvant. The antibody response seen in the two cases is compared. The duration of the immune response from the two schedules is exhibited.
引用
收藏
页码：R5 / R8
页数：4
相关论文
共 50 条
  • [1] In vitro release study of diphtheria toxoid loaded chitosan microspheres
    Kumar, A. Saravana
    Saravanan, V. S.
    Vanitha, J.
    Mohanpaj, P.
    Shivakumar, T.
    [J]. ASIAN JOURNAL OF CHEMISTRY, 2007, 19 (05) : 3532 - 3536
  • [2] Enhanced Immune Response after Subcutaneous Injection of Diphtheria Toxoid-Loaded Bioerodible Microspheres
    Cho, Seong-Wan
    Lee, Sang Kil
    Kang, Myung Joo
    Ye, Jin Soo
    Choi, Yoon Bae
    Hong, Soon Wook
    Lee, Jaehwi
    Choi, Young Wook
    [J]. TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2009, 6 (12) : 1166 - 1171
  • [3] Reduced immunogenicity of diphtheria and tetanus toxoids when combined with pertussis toxoid
    Trollfors, B
    Taranger, J
    Lagergård, T
    Sundh, V
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2005, 24 (01) : 85 - 86
  • [4] Evaluation of Biodegradable Microparticles for Mucosal Vaccination Against Diphtheria Toxoid: Nasal Efficacy Studies in Guinea Pigs
    Coban, Selin
    Saka, Ongun Mehmet
    Bozkir, Asuman
    [J]. TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 20 (05) : 294 - 301
  • [5] Studies on the purification of alum precipitated diphtheria toxoid
    Seal, SC
    Johnson, SJ
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1941, 69 : 102 - 107
  • [6] Estimation of antigenic tetanus toxoid extracted from biodegradable microspheres
    Xing, DKL
    McLellan, K
    Corbel, MJ
    Sesardic, D
    [J]. BIOLOGICALS, 1996, 24 (01) : 57 - 65
  • [7] DIPHTHERIA TOXOID
    不详
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1947, 134 (13): : 1140 - 1140
  • [8] Transcutaneous Immunization Studies in Mice Using Diphtheria Toxoid-Loaded Vesicle Formulations and a Microneedle Array
    Ding, Zhi
    Bal, Suzanne M.
    Romeijn, Stefan
    Kersten, Gideon F. A.
    Jiskoot, Wim
    Bouwstra, Joke A.
    [J]. PHARMACEUTICAL RESEARCH, 2011, 28 (01) : 145 - 158
  • [9] Transcutaneous Immunization Studies in Mice Using Diphtheria Toxoid-Loaded Vesicle Formulations and a Microneedle Array
    Zhi Ding
    Suzanne M. Bal
    Stefan Romeijn
    Gideon F. A. Kersten
    Wim Jiskoot
    Joke A. Bouwstra
    [J]. Pharmaceutical Research, 2011, 28 : 145 - 158
  • [10] Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women
    Fortner, Kimberly B.
    Swamy, Geeta K.
    Broder, Karen R.
    Jimenez-Truque, Natalia
    Zhu, Yuwei
    Moro, Pedro L.
    Liang, Jennifer
    Walter, Emmanuel B.
    Heine, R. Phillips
    Moody, M. Anthony
    Yoder, Sandra
    Edwards, Kathryn M.
    [J]. VACCINE, 2018, 36 (42) : 6354 - 6360
12345