ACUTE CARDIOVASCULAR EFFECTS OF INSULIN IN HYPERGLYCEMIC TYPE-I DIABETICS

被引:1
|
作者
GOTZSCHE, PC
KELBAEK, H
VISSING, SF
NIELSEN, SL
MUNCK, O
CHRISTENSEN, NJ
LYNGSOE, J
MATHIESEN, ER
机构
[1] HERLEV HOSP,DEPT CLIN PHYSIOL & NUCL MED,DK-2730 HERLEV,DENMARK
[2] HERLEV HOSP,DEPT ENDOCRINOL,DK-2730 HERLEV,DENMARK
[3] BISPEBJERG HOSP,DEPT MED C,DK-2400 COPENHAGEN,DENMARK
[4] HVIDOVRE UNIV HOSP,KLAMPENBORG,DENMARK
关键词
INSULIN; INSULIN-DEPENDENT DIABETES MELLITUS; LEFT VENTRICULAR EJECTION FRACTION; RADIONUCLIDE CARDIOGRAPHY;
D O I
10.1080/00365513.1991.11978694
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cardiovascular responses to high-dose (0.100 IE kg-1h-1) and low-dose insulin infusion (0.005-0.01 IE kg-1 h-1) were examined in eight hyperglycaemic, resting type I diabetics. Mean blood glucose dropped from 15.9 to 7.1 mmol 1-1 and from 14.4 to 12.6 mmol 1-1, respectively, during 1 h. Blood pressure and heart rate did not change. There were no significant changes in absolute or relative left ventricular volumes, the 95% confidence interval (CI) for the difference between the doses in left ventricular ejection fraction was -6 to 8%. Calf blood volume increased on high-dose insulin (p=0.05, CI for the difference over low-dose insulin 0.0 to 4.6 ml 100 ml-1 tissue). Blood flow increased with 1.6 ml 100 ml-1 tissue min-1 with high-dose insulin and with 0.6 ml 100 ml-1 tissue min-1 with low-dose (CI for the difference -0.5 to 3.4). Noradrenaline increases were small and there was no difference between the doses (p=0.47).
引用
收藏
页码:93 / 97
页数:5
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