VERONGAMINE, A NOVEL BROMOTYROSINE-DERIVED HISTAMINE H-3 ANTAGONIST FROM THE MARINE SPONGE VERONGULA-GIGANTEA

被引：45
|
作者：
MIERZWA, R
KING, A
CONOVER, MA
TOZZI, S
PUAR, MS
PATEL, M
COVAL, SJ
POMPONI, SA
机构：
[1] SCHERING PLOUGH RES INST,KENILWORTH,NJ 07033
[2] HARBOR BRANCH OCEANOG INST INC,FT PIERCE,FL 34946
来源：
JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 01期
关键词：
D O I：
10.1021/np50103a029
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The novel bromotyrosine derivative verongamine [1] has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H-3 bioassay-guided fractionation. Verongamine is a specific histamine-H-3 antagonist at concentrations as low as 1 mu g/ml.
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页码：175 / 177
页数：3
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