Effect of pH and glutathione on lipid peroxidation in tocopherol-enriched liposomes

被引：2
|
作者：
Dmitriev, LF [1 ]
Ivanova, MV [1 ]
Lebedev, AV [1 ]
机构：
[1] CARDIOL RES CTR, MOSCOW 121552, RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 120卷 / 09期
关键词：
liver microsomes; tocopherol; glutathione;
D O I：
10.1007/BF02445013
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Tocopherol-enriched liver microsomes are more resistant to lipid peroxidation at an alkaline pH of 8.5 in comparison with microsomes incubated at pH 7.5. An alkaline pH provides conditions for two-electron oxidation of tocopherol, which causes the lipid molecule to revert to the initial state (O-2/H exchange). A possible mechanism of inhibition of lipid peroxidation within the physiological range of pH with participation of a glutathione-dependent enzyme is discussed.
引用
收藏
页码：908 / 910
页数：3
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