THE NA+-INDEPENDENT CA-2+ EFFLUX SYSTEM IN MITOCHONDRIA IS A CA-2+ 2H+ EXCHANGE SYSTEM

被引：26
|
作者：
ROTTENBERG, H
MARBACH, M
机构：
[1] Pathology Department, Hahnemann University, Philadelphia
来源：
FEBS LETTERS | 1990年 / 274卷 / 1-2期
关键词：
Ca[!sup]2+[!/sup; Ca[!sup]2+[!/sup]/2H[!sup]+[!/sup] exchange; Cyclosporin A; Mitochondria; ΔpH;
D O I：
10.1016/0014-5793(90)81330-Q
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanism of the Na+-independent Ca2+ efflux system in mitochondria has not been elucidated as yet. With the aid of cyclosporin A. an inhibitor of the Ca2+-induced 'pore', and using a variety of inhibitors, uncouplers and lonophores, it is possible to demonstrate, unequivocally, that this process is driven by ΔpH. The efflux is not affected by ΔΨ, thus suggesting an electroneutral Ca2+/2H+ exchange mechanism. Parallel measurements of the rate of Ca2+ efflux and ΔpH, as modulated by valinomycin and nigericin, indicate that the rate of efflux is a function of the magnitude of ΔpH. © 1990.
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页码：65 / 68
页数：4
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