GLUCOCORTICOIDS AND ATRIAL-NATRIURETIC-FACTOR RECEPTORS ON VASCULAR SMOOTH-MUSCLE

被引:42
|
作者
YASUNARI, K
KOHNO, M
MURAKAWA, K
YOKOKAWA, K
TAKEDA, T
机构
[1] First Dept. of Internal Medicine, Osaka City University Medical School, Osaka
[2] First Dept. of Internal Medicine, Osaka City University Medical School, Abeno-ku, Osaka 545, 1-5-7, Asahi-machi
关键词
Aldosterone; Atrial natriuretic factor; Dexamethasone; Glucocorticoids; Testosterone; Vascular smooth muscle;
D O I
10.1161/01.HYP.16.5.581
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The effect of glucocorticoids on the atrial natriuretic factor (ANF)-mediated formation of cyclic guanosine monophosphate (cGMP) by intact vascular smooth muscle cells (VSMC) was studied in rats. Cultured VSMC were obtained from the renal arteries of 14-week-old Wistar rats by the expiant method. Micromolar concentrations of dexamethasone, given as pretreatment for 48 hours, suppressed the ANF-mediated response. The dexamethasone-induced suppression was detectable at 6 hours and reached a maximum 24 hours after administration in a dose-dependent manner. Inhibitors of protein synthesis blocked this effect of the glucocorticoid. The basal activity of guanylate cyclase in the dexamethasone-treated cells was lower than in the control cells. Other steroids having glucocorticoid action mimicked this suppression of the ANF-mediated response. This suppression was blocked by a glucocorticoid receptor antagonist. The results suggest that glucocorticoids suppress ANF-mediated cGMP formation by VSMC through glucocorticoid type II receptors and the induction of protein synthesis. Suppression of the ANF-mediated response may play a role in glucocorticoid-induced hypertension.
引用
收藏
页码:581 / 586
页数:6
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