The outcome of treatment in 40 patients (42 knees) with chronic infections after total knee arthroplasty was reviewed, Eighteen knees were treated with a 2-stage reimplantation, Sixteen of these 18 knees were treated with antibiotic-containing beads between debridement and reimplantation, and 7 of these were also treated with antibiotics in the cement at reimplantation, Infection did not recur in any of these 18 knees, Clinically, the 2-stage reimplantation group averaged a score of 90 points on the Knee Society Clinical Rating System, Average function score was 86.5 points, with average range of motion from 2 degrees to 109 degrees, Sixteen knees were treated with an arthrodesis: 9 with a 1-stage technique with a uniplanar external fixator and 7 with a 2-stage technique with intramedullary nail internal fixation, Infection did not recur in 6 of 9 knees treated with the 1-stage technique, but only 2 had a solid arthrodesis. All 7 treated with the 2-stage intramedullary nail technique had no recurrence of infection and achieved a solid fusion, Reimplantation or arthrodesis was not attempted in 8 other knees because of recalcitrant infection, vascular complications, or medical infirmity. Of the 42 knees, 11 (26%) had a severely morbid outcome, The infection could not be eradicated in 7 knees: 6 required amputation and 1 had a solid fusion but chronic drainage, In 3 knees, the infection was cured but resection arthroplasties were required, and in 1 patient an amputation was needed as a result of an intraoperative vascular complication.