HLA-A, B, C AND DR ANTIGENS IN NICKEL CONTACT SENSITIVITY

被引：16
|
作者：
MOZZANICA, N [1 ]
RIZZOLO, L [1 ]
VENERONI, G [1 ]
DIOTTI, R [1 ]
HEPEISEN, S [1 ]
FINZI, AF [1 ]
机构：
[1] OSPED FATEBENEFRATELLI OFTALMICO, DEPT IMMUNOHAEMATOL, MILAN, ITALY
来源：
BRITISH JOURNAL OF DERMATOLOGY | 1990年 / 122卷 / 03期
关键词：
D O I：
10.1111/j.1365-2133.1990.tb08278.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The relationship between HLA antigens (A, B, C and DR) and nickel contact sensitivity was examined in 54 patients with contact allergy, as confirmed by an unequivocal positive patch-test reaction only to nickel. A control group was 320 healthy blood donors from the same geographical area as the patients. The HLA-A, B, C and DR antigens were typed using standard serological methods. HLA typing revealed a significant increase of HLA-DRw6 antigen in the patient group (corrected P < 0.025) and the relative risk for patients with DRw6 to develop nickel sensitivity was 3.32.
引用
收藏
页码：309 / 313
页数：5
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