A VACCINIA VIRUS HERPES-SIMPLEX VIRUS (HSV) GLYCOPROTEIN B1 RECOMBINANT OR AN HSV VACCINE OVERCOME THE HSV TYPE-2 INDUCED HUMORAL IMMUNOSUPPRESSION AND PROTECT AGAINST VAGINAL CHALLENGE IN BALB/C MICE

被引：6
|
作者：
FLECK, M [1 ]
PODLECH, J [1 ]
WEISE, K [1 ]
FALKE, D [1 ]
机构：
[1] INST MED MICROBIOL,DIV EXPTL VIROL,D-55101 MAINZ,GERMANY
来源：
MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 1994年 / 183卷 / 02期
关键词：
D O I：
10.1007/BF00277159
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Primary infections with herpes simplex virus type 2 (HSV-2) suppress the antibody response to secondary HSV-1 and -2 infections in the BALB/c mouse. In contrast, a challenge by the i.p. route using a vaccinia virus-HSV-1 glycoprotein B (VV gB 1) recombinant induces a significant enhancement of the antibody response. This booster reaction is also observed if a challenge with a formalin-inactivated HSV-1 vaccine is performed. Although no or low humoral and vaginal antibodies are detectable after a single i.p. infection with the VV gB1 recombinant or the HSV-1 vaccine, protection against vaginal challenge with HSV-2 is induced. This points to the important role of cellular immunity for vaginal infections.
引用
收藏
页码：87 / 94
页数：8
相关论文
共 50 条
  • [1] HERPES-SIMPLEX VIRUS (HSV)-SPECIFIC HUMAN T-CELL CLONES RECOGNIZE HSV GLYCOPROTEIN-D EXPRESSED BY A RECOMBINANT VACCINIA VIRUS
    ZARLING, JM
    MORAN, PA
    LASKY, LA
    MOSS, B
    JOURNAL OF VIROLOGY, 1986, 59 (02) : 506 - 509
  • [2] RECOMBINANT VACCINIA VIRUS EXPRESSING THE HERPES-SIMPLEX VIRUS TYPE-1 GLYCOPROTEIN-C PROTECTS MICE AGAINST HERPES-SIMPLEX VIRUS CHALLENGE
    WEIR, JP
    BENNETT, M
    ALLEN, EM
    ELKINS, KL
    MARTIN, S
    ROUSE, BT
    JOURNAL OF GENERAL VIROLOGY, 1989, 70 : 2587 - 2594
  • [3] ACTIVATION OF HERPES-SIMPLEX VIRUS (HSV) TYPE-1 GENOME BY TEMPERATURE-SENSITIVE MUTANTS OF HSV TYPE-2
    WIGDAHL, BL
    ISOM, HC
    DECLERCQ, E
    RAPP, F
    VIROLOGY, 1982, 116 (02) : 468 - 479
  • [4] PROTECTION OF GUINEA-PIGS FROM PRIMARY AND RECURRENT HERPES-SIMPLEX VIRUS (HSV) TYPE-2 CUTANEOUS DISEASE WITH VACCINIA VIRUS RECOMBINANTS EXPRESSING HSV GLYCOPROTEIN-D
    WACHSMAN, M
    AURELIAN, L
    SMITH, CC
    LIPINSKAS, BR
    PERKUS, ME
    PAOLETTI, E
    JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (06): : 1188 - 1197
  • [5] PROTECTIVE ACTIVITY OF RECOMBINANT CYTOKINES AGAINST SENDAI VIRUS AND HERPES-SIMPLEX VIRUS (HSV) INFECTIONS IN MICE
    IIDA, J
    SAIKI, I
    ISHIHARA, C
    AZUMA, I
    VACCINE, 1989, 7 (03) : 229 - 233
  • [6] BACULOVIRUS-EXPRESSED HERPES-SIMPLEX VIRUS TYPE-2 GLYCOPROTEIN-D IS IMMUNOGENIC AND PROTECTIVE AGAINST LETHAL HSV CHALLENGE
    LANDOLFI, V
    ZARLEY, CD
    ABRAMOVITZ, AS
    FIGUEROA, N
    WU, SL
    BLASIAK, M
    ISHIZAKA, ST
    MISHKIN, EM
    VACCINE, 1993, 11 (04) : 407 - 414
  • [7] ANTIBODY-RESPONSE TO HERPES-SIMPLEX VIRUS TYPE-2 (HSV-2) VACCINE IN HUMANS
    ASHLEY, RL
    CLARK, H
    SCHICK, M
    COREY, L
    CLINICAL RESEARCH, 1983, 31 (02): : A358 - A358
  • [8] REGULATION OF EXPRESSION OF HERPES-SIMPLEX VIRUS (HSV) GLYCOPROTEIN-D IN VACCINIA RECOMBINANTS AFFECTS THEIR ABILITY TO PROTECT FROM CUTANEOUS HSV-2 DISEASE
    WACHSMAN, M
    AURELIAN, L
    SMITH, CC
    PERKUS, ME
    PAOLETTI, E
    JOURNAL OF INFECTIOUS DISEASES, 1989, 159 (04): : 625 - 634
  • [9] PROTECTION OF MICE AGAINST LETHAL CHALLENGE WITH HERPES-SIMPLEX VIRUS BY VACCINATION WITH AN ADENOVIRUS VECTOR EXPRESSING HSV GLYCOPROTEIN-B
    MCDERMOTT, MR
    GRAHAM, FL
    HANKE, T
    JOHNSON, DC
    VIROLOGY, 1989, 169 (01) : 244 - 247
  • [10] EXPERIMENTAL FINDINGS THAT PRIOR INFECTION WITH HERPES-SIMPLEX VIRUS (HSV) TYPE-1 PREVENTS SUBSEQUENT INFECTION WITH HSV TYPE-2
    AMSTEY, MS
    JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (03): : 679 - 679
12345