CALCIUM-SENSITIVE INACTIVATION IN THE GATING OF SINGLE CALCIUM CHANNELS

被引：172
|
作者：
YUE, DT
BACKX, PH
IMREDY, JP
机构：
[1] Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore
来源：
SCIENCE | 1990年 / 250卷 / 4988期
关键词：
D O I：
10.1126/science.2176745
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Voltage-activated calcium channels open and close, or gate, according to molecular transition rates that are regulated by transmembrane voltage and neurotransmitters. Here evidence for the control of gating by calcium was found in electrophysiological records of single, L-type calcium channels in heart cells. Conditional open probability analysis revealed that calcium entry during the opening of a single channel produces alterations in gating transition rates that evolve over the course of hundreds of milliseconds. Such alteration of calcium-channel gating by entry of a favored permeant ion provides a mechanism for the short-term modulation of single-ion channels.
引用
收藏
页码：1735 / 1738
页数：4
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