POTENTIATION OF GABA-INDUCED INHIBITION BY 20-HYDROXYECDYSONE, A NEUROSTEROID, IN CULTURED RAT CORTICAL-NEURONS

被引：14
|
作者：
TSUJIYAMA, S [1 ]
UJIHARA, H [1 ]
ISHIHARA, K [1 ]
SASA, M [1 ]
机构：
[1] YAMAGUCHI UNIV,SCH MED,DEPT PHARMACOL,UBE,YAMAGUCHI 755,JAPAN
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1995年 / 68卷 / 01期
关键词：
GABA; NEUROSTEROID; CULTURED CORTICAL NEURON;
D O I：
10.1254/jjp.68.133
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effects of 20-hydroxyecdysone (20-HE), a neurosteroid, on cultured rat cortical neurons were examined using the whole cell recording technique. Under the voltage and current clamp conditions, brief application (5 sec) of 20-HE alone did not produce current changes nor any changes in the membrane potential. However, the chemical dose-dependently potentiated the GABA-induced current and hyperpolarization, which were blocked by bicuculline. These results suggest that 20-HE acts on the modulatory site of the GABA, receptor and potentiates GABAergic inhibition in rat cortical neurons.
引用
收藏
页码：133 / 136
页数：4
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