ARYL CYANOGUANIDINE POTASSIUM CHANNEL OPENERS

被引：24
|
作者：
ATWAL, KS
MORELAND, S
MCCULLOUGH, JR
OREILLY, BC
AHMED, SZ
NORMANDIN, DE
机构：
[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, N. J. 08543-4000, P.O. Box 4000, Princeton
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期
关键词：
D O I：
10.1016/S0960-894X(00)80661-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To investigate whether potassium channel openers cromakalim (1) and pinacidil (2) share common pharmacophoric features, the combination compound 6a was prepared and evaluated for biological activity. The potent vasorelaxant/antihypertensive activity displayed by 6a and some of its analogs suggest cromakalim (1) and pinacidil (2) may share common pharmacophoric features.
引用
收藏
页码：83 / 86
页数：4
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