Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis

被引：0
|
作者：
Dong, Suzhen [1 ,2 ,3 ]
Duan, Yale [3 ]
Hu, Yinghe [1 ,2 ,3 ]
Zhao, Zheng [3 ]
机构：
[1] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China
[2] East China Normal Univ, Inst Chem & Translat Gen, Shanghai 200062, Peoples R China
[3] East China Normal Univ, Minist Educ, Shanghai Key Lab Brain Funct Gen, Key Lab Brain Funct Gen, 3663 Zhongshan Rd N, Shanghai 200062, Peoples R China
来源：
TRANSLATIONAL NEURODEGENERATION | 2012年 / 1卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; A-beta; APP; BACE1; Presenilins; ApoE; Neprilysin/insulin-degrading enzyme;
D O I：
10.1186/2047-9158-1-18
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is a common neurodegenerative disease characterized clinically by progressive deterioration of memory, and pathologically by histopathological changes including extracellular deposits of amyloid-beta (A-beta) peptides forming senile plaques (SP) and the intracellular neurofibrillary tangles (NFT) of hyperphosphorylated tau in the brain. This review focused on the new developments of amyloid cascade hypothesis with details on the production, metabolism and clearance of A-beta, and the key roles of some important A-beta-related genes in the pathological processes of AD. The most recent research advances in genetics, neuropathology and pathogenesis of the disease were also discussed.
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收藏
页数：12
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