USE OF PSPB RADIOIMMUNOASSAY (RIA) FOR PREGNANCY DIAGNOSIS IN RUMINANTS

Pregnancy specific protein B (PSPB) has been isolated from placental membranes of the cow and sheep. It has been shown that this protein was the first embryonic signal detectable in the maternal circulation. Development of a specific radioimmunoassay (RIA) for PSPB has allowed profiles of this protein to be studied during the pregnancy of many ruminants (ie cow, ewe, goat, mountain goat, cervids) or especially in the cow in case of embryonic mortality or abortion. This paper reviews data obtained with the PSPB RIA in the cow, goat and deer during the post-partum period and establishment of pregnancy. The accuracy of the results of PSPB RIA when used as a method of pregnancy diagnosis has been examined.