Correlation Between the Immunohistochemical Expression Of Basic Fibroblast Growth Factor In Gingival Tissue With The Clinical Periodontal Parameters (Plaque Index, Gingival Index, Bleeding On Probing) And Angiogenesis

The objectives of this study were to investigate the Correlation between clinical periodontal parameters (PLI, GI, and BOP) with immunohistochemical findings (matrix FGF2 and angiogenesis) as well as Correlation between the expressions of matrix basic FGF and angiogenesis. A total of 44 subjects(1530) years old with plaque-induced gingival overgrowth indicated for gingivec to my attending the clinics of the Department of Periodontics at the teaching hospital at College of dentistry-University of Baghdad / Iraq. At time of periodontal surgery, collection of data including: plaque index (PLI), gingival index (GI), and bleeding on probing(BOP) were performed. Gingival tissue were taken from patients undergoing conventional gingivectomy, washed by normal saline, and fixed with 10% formalin for immune his to chemical analysis of bFGF. There were negative correlations between immune his to chemical findings (basic FGF2 and angiogenesis) and clinical periodontal parameters (PLI, GI, and BOP). There was a significant positive correlation between basic FGF and angiogenesis. Basic fibroblast growth factor (bFGF) is important soluble mediator participate in tissue growth during the formation of granulation tissue that takes an essential role in angiogenesis. This adverse correlation may indicate that after scaling and polishing and with the removing of periodontal pathogenic bacteria, inflammatory processes were reduced and healing processes had been started.