AMINOSILANES IN ORGANIC-SYNTHESIS - ADDITION OF ORGANOCOPPER REAGENTS ON GAMMA-BIS(TRIMETHYLSILYL)AMINO-ALPHA-ACETYLENIC AMIDES, ESTERS AND KETONES - STEREOCHEMISTRY AND SOME SYNTHETIC USES

被引：0

作者：

CORRIU, RJP ^{[1
]}

BOLIN, G ^{[1
]}

IQBAL, J ^{[1
]}

MOREAU, JJE ^{[1
]}

VERNHET, C ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,DEPT CHIM ORGAN FINE,CNRS,HETEROCHIM & AMINOACIDES LAB,F-34095 MONTPELLIER 05,FRANCE

来源：

TETRAHEDRON | 1993年 / 49卷 / 21期

关键词：

SILYLAMINES; PROPARGYLAMINES; ORGANOCOPPER REAGENTS; STEREOCHEMISTRY; NITROGEN HETEROCYCLES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereochemical outcome of the carbocupration of gamma-bis(trimethylsilyl)amino-alpha-acetylenic amide, esters and ketone was studied. A judicious choice of substrate, reagent and(or) reaction conditions allows to perform highly stereoselective cis or trans addition. The intermediate vinylic copper adducts, with (E) or (Z) configuration, react with electrophilic reagents to provide short routes to substituted pyrrolinones and pyrroles.

引用

页码：4603 / 4618

页数：16