ORAL BETA-LACTAM ANTIBIOTICS FROM 1960 TO 1994

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作者
NEU, HC
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中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
IN THE LAST 30 YEARS a large number of new beta-lactam antibiotics have been synthesized. Molecular modifications of the beta-acyl side chain have provided agents that meet the needs of changing microbial pathogens, which have successively become more resistant to older agents. Other changes in the molecules have yielded agents with markedly improved oral pharmacokinetics. This article surveys the various oral beta-lactam agents, with particular stress on the oral cephems.
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页码:S39 / S49
页数:11
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