A NOVEL SERIES OF HIGHLY POTENT 5-LIPOXYGENASE INHIBITORS - 2-ARYLDIENYLBENZOXAZOLES

被引：5
|
作者：
KOSAKA, T [1 ]
OCHIAI, K [1 ]
OHBA, S [1 ]
WAKABAYASHI, T [1 ]
MUROTA, S [1 ]
机构：
[1] TOKYO MED & DENT UNIV,GRAD SCH,DEPT PHYSIOL CHEM,BUNKYO KU,TOKYO 113,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 01期
关键词：
D O I：
10.1016/0960-894X(94)00449-P
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 2-(4-arylbutadienyl)benzoxazole derivatives and an oxazolopyridine derivative were prepared and their 5-lipoxygenase inhibitory activities were evaluated. A number of compounds showed 50% inhibition in the range of 10(-8) similar to 10(-7) M.
引用
收藏
页码：35 / 38
页数：4
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