Regulation of Ras signal transduction during T cell development and activation

被引：0
|
作者：
Lapinski, Philip E. [1 ]
King, Philip D. [1 ]
机构：
[1] Univ Michigan, Med Sch, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
来源：
AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2012年 / 1卷 / 02期
基金：
美国国家卫生研究院;
关键词：
T cells; T cell development; T cell activation; T cell receptor; signal transduction; Ras; Ras GTPase-activating proteins; Ras guanine nucleotide exchange factors;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T cell receptor-induced activation of the Ras signaling pathway is essential for T cell development, proliferation and differentiation. Given the central role of Ras in T cell biology its activation must be tightly regulated. However, precisely how Ras activation is controlled in T cells is not completely understood. In this review, we provide a summary of the known factors and mechanisms involved in positive and negative regulation of Ras activation in the T cell lineage.
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页码：147 / 153
页数：7
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