SKIN-CONDUCTANCE REACTION (SCR)-HABITUATION TEST, AN ELEMENTARY MODEL OF ANXIETY AS A TOOL TO ASSESS ANXIOGENIC ACTIVITIES OF SOME DRUGS

被引：5

作者：

QUERMONNE, MA ^{[1
]}

NAMMATHAO, B ^{[1
]}

LOUCHAHIRAOUL, J ^{[1
]}

MARCY, R ^{[1
]}

机构：

[1] UNIV CAEN, DEPT PHARMACOL, PHARMACEUT SCI UNIT, F-14032 CAEN, FRANCE

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1993年 / 17卷 / 02期

关键词：

AMPHETAMINE; ANXIOGENIC DRUGS; FLUMAZENIL; MICE; NORHARMANE (BETA-CARBOLINE); PIRACETAM; SKIN CONDUCTANCE REACTION; SCR-HABITUATION TEST;

D O I：

10.1016/0278-5846(93)90050-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. The SCR-habituation test, used as a tool to detect an anxiolytic activity, is applied to the study of several anxiogenic drugs. This test is based on the measure of the SCR-extinction time (i.e. habituation) got by the way of an iterative photostimulus. 2. 8 anxiogenic compounds are tested. They delay significantly and quantitatively the SCR habituation. 3. Specificity, sensitivity and quantifying values of the test are considered in order to propose the use of the SCR-habituation test in the investigation of putative anxiogenic compounds.

引用

页码：311 / 318

页数：8

共 4 条

[1] SKIN-CONDUCTANCE REACTION (SCR)-HABITUATION TEST, A TOOL TO DETECT ANXIOLYTIC ACTIVITY - ITS JUSTIFICATION BY THE CORRELATION BETWEEN SCR-HABITUATION TEST ACTIVITIES AND SPECIFIC BINDING POTENCIES IN BENZODIAZEPINES
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[2] SYNTHESIS AND PSYCHOTROPE EVALUATION OF NEW 3-UREIDOPROPAN-2-OLS USING THE SKIN-CONDUCTANCE REACTION (SCR)-HABITUATION TEST
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[4] RECOVERY OF NORMOBARIC HYPOXIA-LOWERED SKIN-CONDUCTANCE RESPONSE (SCR) IN MICE - SCR-HYPOXIA TEST, AN ANIMAL-MODEL FOR TESTING DRUGS AGAINST BRAIN HYPOXIA
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