THE EFFECT OF FOOD ON THE INVIVO BEHAVIOR OF A NOVEL SUSTAINED-RELEASE FORMULATION OF TIAPROFENIC ACID

被引：6
|
作者：
WILDING, IR
DAVIS, SS
SPARROW, RA
BLOOR, JR
HAYES, G
WARD, GT
机构：
[1] UNIV NOTTINGHAM, DEPT PHARMACEUT SCI, NOTTINGHAM NG7 2RD, ENGLAND
[2] QUEENS MED CTR, DEPT HUMAN MORPHOL, NOTTINGHAM NG7 2UH, ENGLAND
[3] ROUSSEL LABS LTD, SWINDON SN3 5BZ, ENGLAND
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 83卷 / 1-3期
关键词：
TIAPROFENIC ACID; SUSTAINED RELEASE; ORAL ADMINISTRATION; GASTROINTESTINAL TRANSIT; PHARMACOSCINTIGRAPHY;
D O I：
10.1016/0378-5173(82)90018-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A novel sustained release tablet formulation of tiaprofenic acid, that has been designed to disintegrate into discrete pellets in the gastrointestinal tract, has been evaluated using a combination of gamma scintigraphy and pharmacokinetics. The performance of the product in vivo was very satisfactory, in that the disintegration of the tableted pellet formulation was rapid. The gastrointestinal transit behaviour of pellets was affected by food, but food did not affect the subsequent absorption of the released drug.
引用
收藏
页码：155 / 161
页数：7
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