Preparation and evaluation of biodegradable microspheres of methotrexate

被引：8
|
作者：
Jayaprakash, S. [1 ]
Halith, S. Mohamed [1 ]
Firthouse, P. U. Mohamed [1 ]
Kulaturanpillai, K. [1 ]
Abhijith [1 ]
Nagarajan, M. [1 ]
机构：
[1] KM Coll Pharm, Dept Pharmaceut, Madurai 625107, Tamil Nadu, India
来源：
ASIAN JOURNAL OF PHARMACEUTICS | 2009年 / 3卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Bovine serum albumin; methotrexate; scanning electron micrographs;
D O I：
10.4103/0973-8398.49171
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The objective of the present study is to prepare sustained-release methotrexate microspheres of bovine serum albumin in different ratios by the emulsion cross-linking method. The prepared microspheres were subjected to various physicochemical evaluation and in vitro release studies. The drug release from microspheres of 1: 6 ratio is the most constant and prolonged drug release is diffusion followed by erosion. The characteristics of the prepared microspheres are conducive to the formulation of the sustained release drug delivery system.
引用
收藏
页码：26 / 29
页数：4
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