PROTEOLIPID DM-20 PREDOMINATES OVER PLP IN PERIPHERAL NERVOUS-SYSTEM

被引：46
|
作者：
PHAMDINH, D
BIRLING, MC
ROUSSEL, G
DAUTIGNY, A
NUSSBAUM, JL
机构：
[1] LAB NEUROBIOL ONTOGEN,CNRS,CTR NEUROCHIM,5 RUE BLAISE PASCAL,F-67084 STRASBOURG,FRANCE
[2] UNIV PARIS 05,PROTEINES LAB,CNRS,URA 1188,F-75270 PARIS 06,FRANCE
来源：
NEUROREPORT | 1991年 / 2卷 / 02期
关键词：
PLP; DM-20; PROTEOLIPID; MYELIN; IMMUNOBLOTTING; PCR;
D O I：
10.1097/00001756-199102000-00006
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THE major central nervous system (CNS) myelin proteolipid (PLP) is also expressed in the peripheral nervous system (PNS). This paper gives evidence that DM-20, an isoform of PLP, also occurs in rat sciatic nerves, where, in contrast to what is seen in CNS myelin, it predominates over PLP. This conclusion was reached on the basis of results obtained by immunoblot analysis of a crude proteolipid extract from adult peripheral nerve with two site-specific anti-proteolipid (PLP and DM-20) antibodies. This finding was further corroborated by characterization of the products obtained by Polymerase Chain Reaction (PCR) amplification of cDNAs synthesized from total RNA of 14-day-old sciatic nerves. The significance of the occurrence of these proteolipids in PNS remains obscure.
引用
收藏
页码：89 / 92
页数：4
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