ASYMMETRIC-SYNTHESIS OF A NOVEL PHENYLOGOUS AMINO-ACID MIMICKING AN EXTENDED DIPEPTIDE

被引：19

作者：

CHEN, L

TRILLES, RV

TILLEY, JW

机构：

[1] Roche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 48期

关键词：

D O I：

10.1016/0040-4039(95)01877-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of an orthogonally protected form of phenylogous amino acid I which mimics an extended conformation of the dipeptide Arg-Gly was achieved. Key steps involve a diastereoselective addition of allylic organometallic reagents to chiral imine 2 and a palladium mediated carboalkoxylation of aryl bromide 5.

引用

页码：8715 / 8718

页数：4

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