INCIDENCE AND LEVEL OF EXOTOXIN-A IN PROTEOLYTIC CELL-FREE CULTURES OF CLINICAL ISOLATES OF PSEUDOMONAS-AERUGINOSA COLLECTED FROM HOSPITALS IN RIYADH, SAUDI-ARABIA

被引：0

作者：

ALSSUM, RM

机构：

来源：

MICROBIOLOGICA | 1992年 / 15卷 / 04期

关键词：

PSEUDOMONAS-AERUGINOSA ENZYMES; PSEUDOMONAS AERUGINOSA EXOTOXIN-A;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mice lethality bioassay revealed that out of 102 proteolytic cell-free cultures of Pseudomonas aeruginosa only 17 (15%) were lethal with values of 19-48 LD50/ml. Antitoxin A antiserum neutralized the lethality providing evidence that the main lethal compound in the cell free cultures was exotoxin A. The neutralization also ruled out the lethal contribution of protease, elastase and phospholipase c. The presence of exotoxin A in a proteolytic environment may indicate less efficient proteolytic action at the stage of toxin production.

引用

页码：355 / 360

页数：6

共 5 条

[1] ANTIMICROBIAL SUSCEPTIBILITIES OF CLINICAL ISOLATES OF PSEUDOMONAS-AERUGINOSA TO 8 ANTIBIOTICS IN RIYADH, SAUDI-ARABIA
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IRCS MEDICAL SCIENCE-BIOCHEMISTRY, 1986, 14 (02): : 178 - 179
[2] IMMUNOENZYMOMETRIC ASSAYS FOR ALKALINE PROTEASE AND EXOTOXIN-A FROM PSEUDOMONAS-AERUGINOSA - DEVELOPMENT AND USE IN DETECTING EXOPROTEINS IN CLINICAL ISOLATES FROM PATIENTS WITH CYSTIC-FIBROSIS
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[3] Antimicrobial resistance among clinical isolates of Pseudomonas aeruginosa from patients in a teaching hospital, Riyadh, Saudi Arabia, 2001-2005
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ANTIBIOTICS-BASEL, 2021, 10 (08):

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