A CATALYTIC ENANTIOSELECTIVE REACTION USING A C2-SYMMETRICAL DISULFONAMIDE AS A CHIRAL LIGAND - ALKYLATION OF ALDEHYDES CATALYZED BY DISULFONAMIDE-TI(O-ISO-PR)4-DIALKYL ZINC SYSTEM

被引：0

作者：

TAKAHASHI, H ^{[1
]}

KAWAKITA, T ^{[1
]}

OHNO, M ^{[1
]}

YOSHIOKA, M ^{[1
]}

KOBAYASHI, S ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON | 1992年 / 48卷 / 27期

关键词：

CHIRAL DISULFONAMIDE; CHIRAL TITANIUM COMPLEX; ENANTIOSELECTIVE ALKYLATION; DIALKYL ZINC; CATALYTIC REACTION;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Excellent enantioselective alkylation of aldehydes with dialkylzinc has been developed. This methodology is based on the concept of modifying the Lewis acid with a C2-symmetric, electron-withdrawing disulfonamide. The chiral Lewis acid catalysts used in the present study are the titanium complex, prepared in-situ from disulfonamide and Ti(O-i-Pr)4.

引用

页码：5691 / 5700

页数：10

共 3 条

[1] ENANTIOSELECTIVE ALKYLATION OF ALDEHYDE CATALYZED BY DISULFONAMIDE-TI(O-ISO-PR)4-DIALKYL ZINC SYSTEM
TAKAHASHI, H
KAWAKITA, T
YOSHIOKA, M
KOBAYASHI, S
OHNO, M
TETRAHEDRON LETTERS, 1989, 30 (50) : 7095 - 7098
[2] A CATALYTIC ENANTIOSELECTIVE REACTION USING A C2-SYMMETRICAL DISULFONAMIDE AS A CHIRAL LIGAND - CYCLOPROPANATION OF ALLYLIC ALCOHOLS BY THE ET2ZN-CH2I2-DISULFONAMIDE SYSTEM
TAKAHASHI, H
YOSHIOKA, M
OHNO, M
KOBAYASHI, S
TETRAHEDRON LETTERS, 1992, 33 (18) : 2575 - 2578
[3] A CATALYTIC ENANTIOSELECTIVE REACTION USING A C-2-SYMMETRICAL DISULFONAMIDE AS A CHIRAL LIGAND - SIMMONS-SMITH CYCLOPROPANATION OF ALLYLIC ALCOHOLS BY THE ET(2)ZN-CH2I2-DISULFONAMIDE SYSTEM
TAKAHASHI, H
YOSHIOKA, M
SHIBASAKI, M
OHNO, M
IMAI, N
KOBAYASHI, S
TETRAHEDRON, 1995, 51 (44) : 12013 - 12026

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