IMMUNIZATION OF CALVES WITH OSTERTAGIA-OSTERTAGI 4TH STAGE LARVAL ANTIGENS FAILED TO PROTECT CALVES FROM INFECTION

被引：12
|
作者：
HILDERSON, H
BERGHEN, P
DE GRAAF, DC
CLAEREBOUT, E
VERCRUYSSE, J
机构：
[1] Department of Parasitology, Faculty of Veterinary Medicine, University of Gent, 9280 Merelbeke
来源：
INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1995年 / 25卷 / 06期
关键词：
CATTLE; OSTERTAGIA OSTERTAGI; 4TH-STAGE LARVAE (L4); EXCRETORY-SECRETORY ANTIGENS; SOMATIC ANTIGENS; IMMUNIZATION;
D O I：
10.1016/0020-7519(94)00196-U
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Excretory-secretory and somatic antigens of Ostertagia ostertagi fourth stage larvae, emulsified with complete Freund's adjuvant, were intraperitoneally administered to calves on three occasions. Two weeks after the last immunisation all calves were infected with a single dose of 130,000 O. ostertagi third stage larvae. All animals were necropsied 25 days after infection. The immunisation procedure resulted in IgG1 and IgG2 antibodies, however no protective immunity was induced as O. ostertagi worm burdens and worm length were similar in all groups.
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页码：757 / 760
页数：4
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