ALL-OR-NONE MECHANISM OF THE MOLTEN GLOBULE UNFOLDING

被引：101

作者：

UVERSKY, VN ^{[1
]}

SEMISOTNOV, GV ^{[1
]}

PAIN, RH ^{[1
]}

PTITSYN, OB ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT BIOCHEM & GENET,NEWCASTLE TYNE NE2 4HH,ENGLAND

来源：

FEBS LETTERS | 1992年 / 314卷 / 01期

关键词：

PROTEIN FOLDING; MOLTEN GLOBULE; SIZE EXCLUSION CHROMATOGRAPHY; CARBONIC ANHYDRASE-B; BETA-LACTAMASE;

D O I：

10.1016/0014-5793(92)81468-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Gdm-HCl-induced unfolding of bovine carbonic anhydrase B and S. aureus beta-lactamase was studied at 4-degrees-C by a variety of methods. With the use of FPLC it has been shown that within the transition from the molten globule to the unfolded state the distribution function of molecular dimensions is bimodal. This means that equilibrium intermediates between the molten globule and the unfolded states are absent, i.e. the molten globule unfolding follows the 'all-or-none' mechanism.

引用

页码：89 / 92

页数：4

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