AN OXY-COPE ROUTE TO THE TAXANE AB RING-SYSTEM

被引：0
|
作者：
ZUCKER, PA
LUPIA, JA
机构：
来源：
SYNLETT | 1990年 / 12期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The bridged taxane AB ring system is constucted via an oxy-Cope reaction of 6-hydroxy-7,7-dimethyl-1,6-divinylbicyclo-[3.1.1]heptane. The outcome of the intramolecular ketene-olefin cycloaddition of 2-ethylidene-7-methyl-6-octenoyl chloride used to construct the required oxy-Cope substrate is shown to be highly sensitive to 3-methyl substitution on the chain connecting the ketene and olefin.
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页码：729 / 730
页数：2
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