SERUM ANGIOTENSIN CONVERTING ENZYME-ACTIVITY AND PLASMA-RENIN ACTIVITY IN EXPERIMENTAL-MODELS OF RATS

被引：16
|
作者：
IBARRARUBIO, ME
CRUZ, C
TAPIA, E
PENA, JC
PEDRAZACHAVERRI, J
机构：
[1] INST NACL NUTR SALVADOR ZUBIRAN,DEPT NEFROL & METAB MINERAL,VASCO QUIROGA 15,DELEGAC TLALPAN,MEXICO CITY 14000,MEXICO
[2] INST NACL CARDIOL IGNACIO CHAVEZ,DEPT NEFROL,MEXICO CITY,MEXICO
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1990年 / 17卷 / 06期
关键词：
angiotensin converting enzyme; kininase II; renin; renin‐angiotensin system;
D O I：
10.1111/j.1440-1681.1990.tb01338.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Serum angiotensin converting enzyme activity (ACEA) and plasma renin activity (PRA) were determined in rats under different experimental conditions such as: nephrotic syndrome (NS), bilateral nephrectomy (BN), renovascular hypertension (RH), dehydration (DEH), anaesthesia (AN), low sodium diet (LSD) and high sodium diet (HSD), and injection with propranolol (PRO) and isoprenaline (ISO). 2. PRA increased in LSD, AN, NS, RH, DEH and IPT groups, and decreased in HSD, BN, and PRO groups. Serum ACEA did not change in RH, HSD, IPT, DEH, AN, and PRO groups, increased in NS group, and decreased in LSD and BN groups. 3. Serum ACEA changed in the opposite direction to PRA only in the LSD group. This finding suggests that ACE may limit the full expression of the reninangiotensin system in the LSD group, but not in the other groups. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码：391 / 399
页数：9
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