Aspirin influence on the contingent negative variation in healthy individuals

Alterations in parameters of slow brain potentials (contingent negative variation, CNV) were examined in healthy individuals under influence of aspirin according to double blind method. The early and late waves of CNV were analysed. The significant decrease of early wave of CNV was obtained after aspirin administration. late wave of CNV increased after aspirin and placebo intake. The alterations descripted were explained in terms of central mechanisms of aspirin action including noradrenergic and dopaminergic systems involvement.