Proteomics and Mass Spectrometry for Cancer Biomarker Discovery

被引：0
|
作者：
Lu, Ming [1 ,2 ]
Faull, Kym F.
Whitelegge, Julian P. [3 ]
He, Jianbo [1 ,2 ]
Shen, Dejun [1 ,2 ]
Saxton, Romaine E. [4 ]
Chang, Helena R. [1 ,2 ,4 ]
机构：
[1] UCLA, Gonda, Breast Canc Res Lab, Los Angeles, CA 90095 USA
[2] UCLA, Revlon, Breast Ctr, David Geffen Sch Med,Dept Surg Oncol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Inst Neurosci & Human Behav, Dept Psychiat & Biobehav & Neuropsychiat Semel, Pasarow Mass Spectrometry Lab, Los Angeles, CA 90095 USA
[4] David Geffen Sch Med, Dept Surg, Div Surg Oncol, Los Angeles, CA USA
来源：
BIOMARKER INSIGHTS | 2007年 / 2卷
关键词：
Proteomics; Mass spectrometry; Cancer; Biomarkers;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Proteomics is a rapidly advancing field not only in the field of biology but also in translational cancer research. In recent years, mass spectrometry and associated technologies have been explored to identify proteins or a set of proteins specific to a given disease, for the purpose of disease detection and diagnosis. Such biomarkers are being investigated in samples including cells, tissues, serum/plasma, and other types of body fluids. When sufficiently refined, proteomic technologies may pave the way for early detection of cancer or individualized therapy for cancer. Mass spectrometry approaches coupled with bioinformatic tools are being developed for biomarker discovery and validation. Understanding basic concepts and application of such technology by investigators in the field may accelerate the clinical application of protein biomarkers in disease management.
引用
收藏
页码：347 / 360
页数：14
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