EXPERIMENTAL AUTOIMMUNE NIGRAL DAMAGE IN GUINEA-PIGS

被引：25
|
作者：
LE, WD [1 ]
ENGELHARDT, J [1 ]
XIE, WJ [1 ]
SCHNEIDER, L [1 ]
SMITH, RG [1 ]
APPEL, SH [1 ]
机构：
[1] BAYLOR COLL MED, DEPT NEUROL, HOUSTON, TX 77030 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1995年 / 57卷 / 1-2期
基金：
匈牙利科学研究基金会;
关键词：
DOPAMINERGIC NEURONS; SUBSTANTIA NIGRA; AUTOIMMUNITY; PARKINSONS DISEASE;
D O I：
10.1016/0165-5728(94)00160-P
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
An animal model of experimental autoimmune nigral damage (EAND) has been developed in guinea pigs by immunization with hybrid dopaminergic cells (MES 23.5). In such animals, loss of 40% of the substantia nigra (SN) neurons and damage to an additional 10% of SN neurons was associated with a 37-43% decrease of tyrosine hydroxylase (TH) activity and a 36% decrease of dopamine (DA) content in the nigral-striatum. Eight of the thirteen animals developed significant hypokinesia. The EAND model suggests that degeneration of dopaminergic neurons in SN can be caused by immune-mediated processes, which may help our understanding of the pathogenesis in Parkinson's disease.
引用
收藏
页码：45 / 53
页数：9
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