EFFICIENCY OF GRAPE POLYPHENOLS IN PATIENTS WITH METABOLIC SYNDROME (LITERATURE REVIEW)

Purpose of the review: to study of the efficiency of grape polyphenols in patients with metabolic syndrome. Methodology: A literature search was conducted in electronic databases and publications included in Embase, PubMed/Medline, Science Direct, Springer Link, Cochrane Library, eLibrary. The depth of the literature search was 12 years. More than 30 publications were selected and reviewed, including full-text articles, Systematic Reviews and Meta-Analysis that were published in English. Results and conclusions: Grape polyphenols in supported doses can delay or prevent the onset of metabolic syndrome with reducing body weight, blood pressure and blood glucose levels and improving lipid metabolism. The results indicate that polyphenols are significant metabolic modulators because of their ability to influence different targets of the cellular and molecular pathways. However, some studies have shown inconsistent results and conflicting data on the efficacy of polyphenols in metabolic syndrome management have been obtained. Perhaps, contradictory data are associated with significant limitations of their bioavailability, especially in conditions of progressive metabolic syndrome. Therefore, more extensive and in-depth scientific research are needed to determine more accurately the role of polyphenols in the progression of metabolic syndrome components.