SYNTHETIC STUDIES OF CARBAPENEM AND PENEM ANTIBIOTICS .3. A SYNTHESIS OF A KEY INTERMEDIATE FOR 1-BETA-METHYLCARBAPENEM

被引：0

作者：

SASAKI, A ^{[1
]}

MATSUMURA, H ^{[1
]}

YANO, T ^{[1
]}

TAKATA, S ^{[1
]}

SUNAGAWA, M ^{[1
]}

机构：

[1] SUMITOMO PHARMACEUT CO LTD, RES LABS, 3-1-98 KASUGADE NAKA, KONOHANA KU, OSAKA 554, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 05期

关键词：

1-ALPHA-METHYLCARBAPENEM; 1-BETA-METHYLCARBAPENEM; (3S; 4S)-4-[(R)-1-CARBOXYETHYL]-3-[(R)-1-HYDROXYETHYL]-2-AZETIDINONE; STEREOSELECTIVE HYDROGENATION; STEREOSELECTIVE HYDROBORATION;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We synthesized useful intermediates 5 and 6 for 1-beta- and 1-alpha-methylcarbapenems from 4-carboxy-3-[(R)-1-hydroxyethyl]-2-azetidinone 4 as a starting material by using stereoselective hydrogenation and hydroboration, respectively. A practical synthetic route from 4 to the (3S,4S)4-[(R)-1-carboxyethyl]-3-[(R)-1-hydroxyethyl]-2-azetidinone derivative 1, a useful intermediate for the synthesis of 1-beta-methylcarbapenem antibiotics, was established.

引用

页码：1098 / 1104

页数：7

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