GENETIC MANIPULATION OF THE SHIKIMATE PATHWAY TO OVERPRODUCE AROMATIC-AMINO-ACIDS

被引：0
|
作者：
VENKAT, K
BACKMAN, K
HATCH, RT
机构：
[1] H. J. Heinz Company, Rutgers University
[2] BioTechnica International, Inc., Cambridge, MA
来源：
FOOD BIOTECHNOLOGY | 1990年 / 4卷 / 01期
关键词：
D O I：
10.1080/08905439009549768
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In this paper, we describe a successful approach to genetically modify the shikimate pathway of E. coll to overproduce aromatic amino acids. Every gene in the entire pathway was manipulated and its effect was examined. Based on this analysis, an optimum combination of genes and their expression levels were arrived at to maximize aromatic amino acid production. Feedback repression/inhibition effects are essentially neutralized by this approach. © 1990, Taylor & Francis Group LLC. All rights reserved.
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页码：547 / 547
页数：1
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