A RETROSPECTIVE ANALYSIS OF CSF AND CLINICAL PROFILES DIAGNOSED IN THE CASES OF PYOGENIC MENINGITIS (PM) AND TUBERCULOUS MENINGITIS (TBM) AT NISHTAR HOSPITAL, MULTAN

Objectives: Our research primarily aimed at the laboratory and clinical manifestation of the TB cum bacterial meningitis, the next aim of the research was ratio determination of the protein glucose in cerebrospinal fluid which can be helpful in the condition prediction. Methods: Research design was retrospective which was carried out at Nishtar Hospital, Multan in the time span of Feb, 2016 to Dec, 2017 on the medical records of forty-six cases of the TB and thirty-three cases of the bacterial meningitis. TB meningitis is a disease which is referred to an of above the period of two weeks, tuberculoma and basal enhancement were identified through scan of computerized tomography and with the help of anti-TB therapy response. The definition of the pyogenic meningitis was made as pathogenic isolate response in the fluid of cerebrospinal (bacterial culture) or through a pathogen on cerebrospinal fluid gram stain or positive latex particle agglutination and antibiotic clinical improvements. We also used Logistic regression test for the TB meningitis probability. For the definition of the optimal protein-glucose proportion, diagnosis cutoff point of TB meningitis, with an application of curve of the receiver operating features. Data analysis was carried on SPSS. Results: TB meningitis predictive features were diagnosed as protein to glucose ratio more than 2 (21, OR; CI, 95%; 4.7 - 93); total leukocyte count of the cerebrospinal fluid was under 800 (58, OR; CI, 95%; 5 - 649); and hydrocephalus presence as (19, OR; CI, 95%; 3.3 - 109). Conclusion: We observed a set of simple laboratories, clinical and radiological criteria which can be helpful in the prediction of the TB meningitis. The cerebrospinal fluid value protein to glucose proportion requires validation in the large-scale research studies which can be confirmed through bacteriological TB meningitis case.