GENETIC-MAPPING OF THE BRCA1 REGION ON CHROMOSOME 17Q21

被引：0

作者：

ALBERTSEN, H ^{[1
]}

PLAETKE, R ^{[1
]}

BALLARD, L ^{[1
]}

FUJIMOTO, E ^{[1
]}

CONNOLLY, J ^{[1
]}

LAWRENCE, E ^{[1
]}

RODRIGUEZ, P ^{[1
]}

ROBERTSON, M ^{[1
]}

BRADLEY, P ^{[1
]}

MILNER, B ^{[1
]}

FUHRMAN, D ^{[1
]}

MARKS, A ^{[1
]}

SARGENT, R ^{[1
]}

CARTWRIGHT, P ^{[1
]}

MATSUNAMI, N ^{[1
]}

WHITE, R ^{[1
]}

机构：

[1] UNIV UTAH,HOWARD HUGHES MED INST,SALT LAKE CITY,UT 84112

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 1994年 / 54卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosome 17q21 harbors a gene (BRCA1) associated with a hereditary form of breast cancer, As a step toward identification of this gene itself we developed a number of simple-sequence-repeat (SSR) markers for chromosome 17 and constructed a high-resolution genetic map of a 40-cM region around 17q21. As part of this effort we captured genotypes from five of the markers by using an ABI sequencing instrument and stored them in a locally developed database, as a step toward automated genotyping. In addition, YACs that physically link some of the SSR markers were identified. The results provided by this study should facilitate physical mapping of the BRCA1 region and isolation of the BRCA1 gene.

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页码：516 / 525

页数：10

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