NETWORKING WITH MITOGEN-ACTIVATED PROTEIN-KINASES

被引:65
|
作者
PELECH, SL
CHAREST, DL
MORDRET, GP
SIOW, YL
PALATY, C
CAMPBELL, D
CHARLTON, L
SAMIEI, M
SANGHERA, JS
机构
[1] UNIV BRITISH COLUMBIA,DEPT MED,VANCOUVER,BC,CANADA
[2] KINETEK BIOTECHNOL CORP,VANCOUVER,BC,CANADA
关键词
PROTEIN KINASES; SIGNAL TRANSDUCTION; CELL CYCLE CONTROL;
D O I
10.1007/BF01076767
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Mitogen activated protein (MAP) kinases and their target ribosomal protein S6 (RSK) kinases have been recognized as shared components in the intracellular signaling pathways of many diverse cytokines. Recent studies have extended this protein kinase cascade by identifying the major activator of vertebrate MAP kinases as a serine/threonine/tyrosine-protein kinase called MEK, which is related to yeast mating factor-regulated protein kinases encoded by the STE7 and byr1 genes. MEK, in turn, may be activated following its phosphorylation on serine by either of the kinases encoded by proto-oncogenes raf1 or mos, as well as by p78(mekk), which is related to the yeast STE11 and byr2 gene products. Isoforms of ah of these protein kinases may specifically combine to assemble distinct modules for intracellular signal transmission. However, the fundamental architecture of these protein kinase cascades has been highly conserved during eukaryotic evolution.
引用
收藏
页码:157 / 169
页数:13
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