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National Medical Products Administration Key Lab, for Clinical Research and Evaluation of Innovative Drugs, Institute of Clinical Pharmacology, Dept. of Clinical Pharmacy, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, National Medical Products Administration Key Lab, for Clinical Research and Evaluation of Innovative Drugs, Institute of Clinical Pharmacology, Dept. of Clinical Pharmacy, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University,