STAUROSPORINE BOTH ACTIVATES AND INHIBITS SERINE THREONINE KINASES IN HUMAN PLATELETS

被引：38
|
作者：
KOCHER, M [1 ]
CLEMETSON, KJ [1 ]
机构：
[1] UNIV BERN,THEODOR KOCHER INST,FREIESTR 1,POB 99,CH-3012 BERN,SWITZERLAND
来源：
BIOCHEMICAL JOURNAL | 1991年 / 275卷
关键词：
D O I：
10.1042/bj2750301
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of staurosporine on a selection of protein kinases were investigated with thrombin-stimulated and control human blood platelets. The results demonstrate that staurosporine (1-mu-M) can lead to activation of certain protein kinases in intact platelets and has a general inhibitory effect on the renaturable protein kinases in vitro. New candidates for protein kinases involved in signal transduction are identified.
引用
收藏
页码：301 / 306
页数：6
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