GENOTOXICITY OF BERYLLIUM, GALLIUM AND ANTIMONY IN SHORT-TERM ASSAYS

被引：85
|
作者：
KURODA, K [1 ]
ENDO, G [1 ]
OKAMOTO, A [1 ]
YOO, YS [1 ]
HORIGUCHI, S [1 ]
机构：
[1] OSAKA CITY UNIV,SCH MED,ABENO KU,OSAKA 545,JAPAN
来源：
MUTATION RESEARCH | 1991年 / 264卷 / 04期
关键词：
REC ASSAY; SCE; BERYLLIUM; GALLIUM; ANTIMONY;
D O I：
10.1016/0165-7992(91)90072-C
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The genotoxicity of beryllium, gallium and antimony compounds was studied with the rec, Salmonella mutagenicity and SCE assays. In the rec assay, all the salts of the metals, BeCl2, Be(NO3)2, GaCl3, Ga(NO3)3, SbCl3, SbCl5, and an oxide, Sb2O3, had DNA-damaging activity. None of the compounds was mutagenic to Salmonella. In the SCE assays using V79 cells, 2 antimony(III) compounds, SbCl3 and Sb2O3, and 2 beryllium compounds, BeCl2 and Be(NO3)2, induced SCEs significantly. Sb2O3, slightly soluble in water, was positive in both the rec assay and the SCE assay at very low doses.
引用
收藏
页码：163 / 170
页数：8
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