EFFICACY OF AMPICILLIN VERSUS TRIMETHOPRIM-SULFAMETHOXAZOLE IN A MOUSE MODEL OF LETHAL ENTEROCOCCAL PERITONITIS

被引：26
|
作者：
CHENOWETH, CE [1 ]
ROBINSON, KA [1 ]
SCHABERG, DR [1 ]
机构：
[1] UNIV MICHIGAN,DEPT INTERNAL MED,DIV INFECT DIS,ANN ARBOR,MI 48109
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 09期
关键词：
D O I：
10.1128/AAC.34.9.1800
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Lethal enterococcal peritonitis in mice was used to compare trimethoprim-sulfamethoxazole (TMP-SMX) therapy with ampicillin therapy. Peritoneal fluid showed a 103-CFU decrease in enterococci with ampicillin compared with TMP-SMX. Mortality of the untreated mice was 100%, compared with 40% for ampicillin and 95% for TMP-SMX, despite adequately measured levels in serum and peritoneal fluid.
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页码：1800 / 1802
页数：3
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