Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies

被引：39
|
作者：
Trujillo, Kristina A. [1 ]
Jones, Anna C. [1 ]
Griffith, Jeffrey K. [1 ,2 ]
Bisoffi, Marco [1 ,2 ]
机构：
[1] Univ New Mexico, Hlth Sci Ctr, Dept Biochem & Mol Biol, Albuquerque, NM 87131 USA
[2] Univ New Mexico, Hlth Sci Ctr, New Mexico Canc Ctr, Albuquerque, NM 87131 USA
来源：
PROSTATE CANCER | 2012年 / 2012卷
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1155/2012/302894
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histo-logically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinical value in the analysis of prostate biopsies, including diagnosis, monitoring progression during active surveillance, and assessing efficacy of presurgical neoadjuvant and focal therapeutic interventions.
引用
收藏
页数：12
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