REGULATION OF MYC - MAX COMPLEX-FORMATION AND ITS POTENTIAL ROLE IN CELL-PROLIFERATION

被引:0
|
作者
BLACKWOOD, EM
EISENMAN, RN
机构
[1] WASHINGTON UNIV, SCH MED, DEPT PATHOL, ST LOUIS, MO 63110 USA
[2] FRED HUTCHINSON CANC RES CTR, DIV BASIC SCI, SEATTLE, WA 98104 USA
来源
关键词
BASIC-HELIX-LOOP-HELIX-ZIP (B-HLH-ZIP); DIMERIZATION; MAX; MYC; PROLIFERATION;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The myc family of proto-oncogenes encodes short-lived nuclear phosphoproteins (Myc) involved in the control of cell proliferation and differentiation. Here we discuss the evidence for Myc's involvement in normal and abnormal cell proliferation and review recent information on Max, a novel protein that forms a sequence-specific DNA-binding complex with Myc. The properties of the Myc: Max heterodimeric complex suggest a model for how Myc may function in the cell.
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页码:195 / 202
页数:8
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