IDENTIFICATION OF AN ACUTE-PHASE REACTANT IN MURINE INFECTIONS WITH TRYPANOSOMA-BRUCEI

被引：11
|
作者：
SHAPIRO, SZ [1 ]
BLACK, SJ [1 ]
机构：
[1] INT LAB RES ANIM DIS,NAIROBI,KENYA
来源：
INFECTION AND IMMUNITY | 1992年 / 60卷 / 09期
关键词：
D O I：
10.1128/IAI.60.9.3921-3924.1992
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A 42-kDa protein appeared at a much higher concentration in plasma from Trypanosoma brucei-resistant (C57BL/6) mice after infection than in plasma from trypanosome-susceptible (C3H/He) mice. This protein was purified by sequential steps of gel filtration, protein A-Sepharose affinity chromatography, isoelectric focusing, and ammonium sulfate precipitation. The purified protein was identified as a subunit of the acute-phase reactant haptoglobin. Causes of elevated plasma haptoglobin and its implications for resistance to trypanosomiasis are discussed.
引用
收藏
页码：3921 / 3924
页数：4
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