N-(QUINUCLIDIN-3-YL)-2-(1-METHYL-1H-INDOL-3-YL)-2-OXOACETAMIDE - A HIGH-AFFINITY 5-HT3 RECEPTOR PARTIAL AGONIST

被引：13
|
作者：
CLARK, RD [1 ]
MUCHOWSKI, JM [1 ]
WEINHARDT, KK [1 ]
DILLON, MP [1 ]
LEE, CH [1 ]
BLEY, KR [1 ]
BONHAUS, DW [1 ]
WONG, EHF [1 ]
EGLEN, RM [1 ]
机构：
[1] SYNTEX INC,RES,DEPT PHARMACOL,PALO ALTO,CA 94304
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 16期
关键词：
D O I：
10.1016/0960-894X(95)00308-G
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The enantiomers of the indolyl-2-oxoacetamide 5 were found to have 5-HT3 receptor partial agonist activity with(R)-5 having higher potency than (S)-5.
引用
收藏
页码：1853 / 1856
页数：4
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