MUTATIONAL DNA-BASE SEQUENCE CHANGES IN PLASMID DAMAGED AT A SPECIFIC REGION BY ULTRAVIOLET-LIGHT

被引：2
|
作者：
TAKIMOTO, K
机构：
[1] Radioisotopes Laboratory, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi,753, Japan
来源：
JOURNAL OF RADIATION RESEARCH | 1986年 / 27卷 / 03期
关键词：
Aromatic compounds - Ultraviolet radiation;
D O I：
10.1269/jrr.27.310
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mutational nucleotide sequence changes by ultraviolet light (UV) in the gene for Escherichia coli cAMP receptor protein (CRP) were analyzed. Transitions were most the frequent mutations and occurred at pyrimi-dine-pyrimidine sequences. Most transitions were GC to AT base changes at 3' cytosine of 5'-pyrimidine-cytosine-3' sequences, supporting the concept that pyrimidine (6-4) pyrimidone, Pyr(6-4)Pyo, photoproduct is a principal pre-mutagenic lesion for transition mutations induced by UV. Transversion and frameshift mutations were also found. © 1986 Oxford University Press. All rights reserved.
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页码：310 / 314
页数：5
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