SELECTIVE-INHIBITION OF INDUCIBLE NITRIC-OXIDE SYNTHASE BY AGMATINE

被引：133

作者：

AUGUET, M

VIOSSAT, I

MARIN, JG

CHABRIER, PE

机构：

[1] Institut Henri Beaufour Research Laboratories, ZA de Courtaboeuf, 91952 Les Ulis Cedex, 1, Avenue des Tropiques

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1995年 / 69卷 / 03期

关键词：

AGMATINE; NITRIC OXIDE; INDUCIBLE ENZYME;

D O I：

10.1254/jjp.69.285

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Agmatine was about as potent as aminoguanidine to inhibit the activity of the inducible form of nitric oxide synthase (iNOS) in isolated rat aorta. Like aminoguanidine, agmatine was devoid of significant activity on the constitutive form of NOS. Agmatine inhibited the conversion of [H-3]L-arginine in [3H]L-citrulline in partially purified iNOS from macrophages (IC50 = 262 +/- 39.9 mu M). Thus, our data suggest that agmatine may act as endogenous inhibitor of iNOS.

引用

页码：285 / 287

页数：3

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